Publications

Highlighted below are some of the key publications that have grown out of the Cancer Genomics Program.

Publications:

1. Siu LL, Lawler M, Haussler D, Knoppers BM, Lewin J, Vis DJ, Liao RG, Andre F, Banks I, Barrett JC, Caldas C, Camargo AA, Fitzgerald RC, Mao M, Mattison JE, Pao W, Sellers WR, Sullivan P, Teh BT, Ward RL, ZenKlusen JC, Sawyers CL, Voest EE. Facilitating a culture of responsible and effective sharing of cancer genome data. Nat Med. 2016 May 5; 22(5):464-71. doi: 10.1038/nm.4089. PubMed PMID: 27149219; PubMed Central PMCID: PMC4995884.


2. Spreafico A, Oza AM, Clarke BA, Mackay HJ, Shaw P, Butler M, Dhani NC Lheureux S, Wilson MK, Welch S, Zhang T, Yu C, Stockley T, Siu LL, Kamel-Reid S, Bedard PL. Genotype-matched treatment for patients with advanced type I epithelial ovarian cancer (EOC). Gynecol Oncol. 2017 Jan 3. pii: S0090-8258(16)31620-1. doi: 10.1016/j.ygyno.2016.12.002. [Epub ahead of print] PMID: 28062115


3. Stockley TL, Oza AM, Berman HK, Leighl NB, Knox JJ, Shepherd FA, Chen EX, Krzyzanowska MK, Dhani N, Joshua AM, Tsao MS, Serra S, Clarke B, Roehrl MH, Zhang T, Sukhai MA, Califaretti N, Trinkaus M, Shaw P, van der Kwast T, Wang L, Virtanen C, Kim RH, Razak AR, Hansen AR, Yu C, Pugh TJ, Kamel-Reid S, Siu LL, Bedard PL. Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial. Genome Med. 2016 Oct 25;8(1):109. PMID: 27782854


4. Aung KL, Stockley TL, Serra S, Kamel-Reid S, Bedard PL, Siu LL. Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer. Cold Spring Harb Mol Case Stud. 2016 Sep;2(5):a001016. doi: 10.1101/mcs.a001016. PMID: 27626067


5. Day D, Bedard PL. Beta-Testing of Next-Generation DNA Sequencing for Patients With Advanced Cancers Treated at Community Hospitals. J Oncol Pract. 2016 Apr;12(4):279-81. doi: 10.1200/JOP.2015.010165. PMID: 26957640


6. The AACR Project GENIE Consortium. AACR Project GENIE: Powering Precision Medicine through an International Consortium. Cancer Discov June 26, 2017. DOI: 10.1158/2159-8290.CD-17-0151.


7. Sukhai MA, Craddock KJ, Thomas M, Hansen AR, Zhang T, Siu L, Bedard P, Stockley TL, Kamel-Reid S. A classification system for clinical relevance of somatic variants identified in molecular profiling of cancer. Genet Med. 2016 Feb;18(2):128-36. doi: 10.1038/gim.2015.47. PMID: 25880439


8. TChen, E., Chiu, J., Krzyzanowska, M., Serra., Knox, J., Dhani, N., Mackay, H., Hedley, D., Moore, M., Liu, G., Burkes, R., Brezden-Masley, C., Zhang, T., Yu, C., Kamel-Reid, S., Siu, L., Bedard, PL., Roehrl, M., Craddock, K., Tsao, M. Molecular profiling of patients with advanced colorectal cancer: Princess Margaret Cancer Centre experience. Manuscript submitted for publication.


9. NIkbakht, H., Jessa, S., Sukhai, M.A., Arseneault, M., Zhang., T., Letourneau, L., Thomas, M., Bourgey, M., Moore, M., Geisler, A., Yu. C., Bedard, P.L., Kame-Reid, S., Majewski, J., Siu, L.L., Riazalhosseini, Y., Graham, D., Dormancy and interval therapy affect the evolution in metastatic colorectal cancer. Manuscript submitted for publication.

Abstracts:

1. Philippe L. Bedard, Amit M. Oza, Ming-Sound Tsao, Natasha B. Leighl, Frances A. Shepherd, Eric Xueyu Chen, Ian Tannock, Monika K. Krzyzanowska, Neesha C. Dhani, Blaise Clarke, Hal K. Berman, Stefano Serra, Kenneth J. Craddock, Dianne Chadwick, Tong Zhang, Mahadeo A. Sukhai, Celeste Yu, Aaron Richard Hansen, Suzanne Kamel-Reid, Lillian L. Siu. Princess Margaret Cancer Centre (PMCC) Integrated Molecular Profiling in Advanced Cancers Trial (IMPACT) using genotyping and targeted next-generation sequencing (NGS). ASCO 2013 – Oral Abstract Session, Tumor Biology.


2. Wei-Wu T. Chen, Ian F. Tannock, Hal Berman, Anna Marie Mulligan, Eitan Amir, Albiruni R.A. Razak, Celeste Yu, Suzanne Kamel-Reid, Lillian L. Siu, Philippe L. Bedard. The Princess Margaret (PM) Cancer Centre experience with molecular profiling of metastatic breast cancer (MBC) to screen for genotype-matched clinical trials. EBCC-9 – Oral Presentation, Tomorrow’s Practice Changing Abstracts.


3. Joanne W. Chiu, Philippe L. Bedard, Michael H. Roehrl, Stefano Serra, Monika K. Kryzanowska, Jennifer J. Knox, Helen Mackay, David W. Hedley, Malcolm J. Moore, Geoffrey Liu, Neesha C. Dhani, Suzanne Kamel-Reid, Emina Torlakovic, Tao Wang, Ming-Sound Tsao, Dianne Chadwick, Tong Zhang, Celeste Yu, Eric Xueyu Chen Molecular profiling of patients (pts) with advanced colorectal cancer (CRC): Princess Margaret Cancer Centre experience ASCO GI Cancers Symposium – General Poster Session: Cancers of the Colon and Rectum.


4. Anna Spreafico, Amit M. Oza, Blaise Clarke, Helen Mackay, Patricia Shaw, Golnar Rasty, Marcus O. Butler, Neesha C. Dhani, Stephanie Lheureux, Michelle Wilson, Stephen Welch, Lillian L. Siu, Tong Zhang, Celeste Yu, Geeta D Krishna, Helen Chow, Tracy Stockley, Suzanne Kamel-Reid, Philippe L. Bedard. Genotype matched treatment for patients with advanced type I epithelial ovarian cancer (EOC). ASCO 2014 – Oral Abstract Session, Gynecologic Cancer [Merit Award and NOYCIA for Dr. A. Spreafico]


5. Donna M. Graham, Madeleine Arseneault, Mahadeo A. Sukhai, Louis Letourneau, Mehran Karimzadeh, Tong Zhang, Mariam Thomas, Michael H. A. Roehrl, Eric Xueyu Chen, Monika K Krzyzanowska, Malcolm J. Moore, Amanda Giesler, Celeste Yu, Philippe L. Bedard, Suzanne Kamel-Reid, Lillian L. Siu, Yasser Riazalhosseini. Analysis of clonal evolution of colorectal cancer. ASCO 2014 – Oral Abstract Session, Gastrointestinal (Colorectal Cancer)

Manuscripts:

1. Blanchette PS, Spreafico A, Miller FA, Chan K, Bytautas J, Kang S, Bedard PL, Eisen A, Potanina L, Holland J, Kamel-Reid S, McPherson JD, Razak AR, Siu LL. Genomic testing in cancer: Patient knowledge, attitudes, and expectations. Cancer. 2014 Jun 24. doi: 10.1002/cncr.28807. [Epub ahead of print] PubMed PMID: 24962202


2. Bedard PL, Hansen AR, Ratain MJ, Siu LL. Tumour heterogeneity in the clinic. Nature. 2013 Sep 19;501(7467):355-64. doi: 10.1038/nature12627. PubMed PMID: 24048068.


3. Sleijfer S, Bogaerts J, Siu LL. Designing transformative clinical trials in the cancer genome era. J Clin Oncol. 2013 May 20;31(15):1834-41. doi: 10.1200/JCO.2012.45.3639. Epub 2013 Apr 15. Review. PubMed PMID: 23589555


4. Hansen AR, Bedard PL. Clinical application of high-throughput genomic technologies for treatment selection in breast cancer. Breast Cancer Res. 2013;15(5):R97. PubMed PMID: 24135425; PubMed Central PMCID: PMC3979162.


5. Chen TW, Bedard PL. Personalized medicine for metastatic breast cancer. Curr Opin Oncol. 2013 Nov;25(6):615-24. doi: 10.1097/CCO.0000000000000015. Review. PubMed PMID: 24097103.


6. Tran B, Brown AM, Bedard PL, Winquist E, Goss GD, Hotte SJ, Welch SA, Hirte HW, Zhang T, Stein LD, Ferretti V, Watt S, Jiao W, Ng K, Ghai S, Shaw P, Petrocelli T, Hudson TJ, Neel BG, Onetto N, Siu LL, McPherson JD, Kamel-Reid S, Dancey JE. Feasibility of real time next generation sequencing of cancer genes linked to drug response: results from a clinical trial. Int J Cancer. 2013 Apr 1;132(7):1547-55. doi: 10.1002/ijc.27817. Epub 2012 Oct 11. PubMed PMID: 22948899.


7. Tran B, Dancey JE, Kamel-Reid S, McPherson JD, Bedard PL, Brown AM, Zhang T, Shaw P, Onetto N, Stein L, Hudson TJ, Neel BG, Siu LL. Cancer genomics: technology, discovery, and translation. J Clin Oncol. 2012 Feb 20;30(6):647-60. doi: 10.1200/JCO.2011.39.2316. Epub 2012 Jan 23

Oral Presentations:

1. Rodriguez Freixinos V, Lheureux S, Mandilaras V, Clarke B, Dhani N, Mackay H, Butler M, Wang L, Siu LL, Kamel-Reid S, Stockley T, Bedard P, Oza AM. Integration of somatic molecular profiling for rare epithelial gynaecologic cancer patients. 2016 ASCO Annual Meeting. Abst 5509

Posters:

1. Garg S, Sukhai MA, Misyura M, Thomas M, Zhang T, Siu LL, Bedard PL, Stockley TL, Kamel-Reid S. Impact of TP53 status and molecular classification on molecular profiles in breast cancer subtypes. 2016 AACR Annual Meeting, April 16-20, 2016, New Orleans, LA.


2. Mandilaras V, Garg S, Burnier J, Karakasis K, Wang L, Mackay H, Dhani NC, Butler MO, Rodriguez-Freixinos V, Wilson MK, Martin-Lorente C, Ethier J, Bedard PL, Siu LL, Clarke B, Shaw PA, Stockley T, Oza AM, Lheureux S. P53 Functional Mutation Type in High Grade Serous Ovarian Cancer and Clinical Outcomes. 2016 ASCO Annual Meeting. Abst 5550


3. Stjepanovic N, Bedard PL, Oza A, Clarke B, Krzyzanowska M, Jang R, Dhani N, Leighl N, Gupta A, Elser C, McCuaig J, Aronson M, Holter S, Semotiuk K, Ahmed L, Wang L, Stockley T, Kamel-Reid S, Siu LL, Kim RH. Incidental germline findings identified in a somatic genomic sequencing program for advanced cancer patients. 2016 ASCO Annual Meeting. Abst 1532


4. Turner S, Alizadeh M, Leigh N, Shepherd FA, Zadeh G, Laperriere N, Millar BA, Bernstein M, Bedard PL, Chung C. Effect of Molecular Profile in Non-Small Cell Lung Carcinoma on the development of Brain Metastases. 2016 ASCO Annual Meeting. 2016 Jun. Abst 170342


5. Stjepanovic N, Wilson MK, Mandilaras V, Clarke B, Berman HK, Kim RH, Lheureux S, Randall-Armel S, McCuaig J, Volenik A, Demsky R, Chow H, Mysura M, Siu L, Bedard PL, Kamel-Reid S, Stockley T, Oza A. Germline and somatic multi-gene sequencing in patients with advanced high grade serous ovarian cancer and triple negative breast cancer. 2016 ESMO Annual Symposium. Abst 1547P


6. Stjepanovic N, Garg S, Berman HK, Warr D, Amir E, Cescon D, Elser C, Wang L, Kamel-Reid S, Siu LL, Bedard PL, Stockley T. Impact of TP53 functional mutation type on clinical outcomes of advanced breast cancer patients. 2016 San Antonio Breast Cancer Symposium (SABCS). Abst 923


7. Stjepanovic N, Kim RH, Wilson MK, Mandilaras V, Berman HK, Warr D, Amir E, Cescon D, Elser C, Randall-Armel S, McCuaig J, Volenik A, Demsky R, Chow H, Mysura M, Wang L, Oza A, Kamel-Reid S, Stockley T, Bedard PL. Clinical outcomes of patients with advanced triple negative breast cancer with germline and somatic variants in homologous recombination genes. 2016 San Antonio Breast Cancer Symposium (SABCS). Abst 1128