Genomics Evidence Neoplasia Information Exchange (GENIE)

AACR Project GENIE (Genomics Evidence Neoplasia Information Exchange) is an international data‑sharing consortium led by the American Association for Cancer Research that aggregates, harmonizes, and links clinical‑grade cancer genomic sequencing data with longitudinal clinical outcomes from patients treated at leading cancer centers worldwide, creating a large, publicly accessible real‑world clinico‑genomic registry to accelerate precision oncology research, drug discovery, and clinical trial design. The consortium was established to overcome the limitations of single‑institution datasets by pooling data across centers using common data standards and a strong governance framework, enabling statistically powered analyses across cancer types. Importantly, University Health Network (UHN), through the Princess Margaret Cancer Centre, was one of 7 founding members of AACR Project GENIE, helping to shape the consortium from its inception and contributing extensively to its growth and scientific impact. Over the past decade, the consortium has expanded substantially, and now comprises 22 member institutions across 7 countries on 3 continents, underscoring the sustained growth, scientific trust, and global reach of the initiative.

The registry, after its 19th public data release, now includes 271,837 de-identified genomic records collected from 227,696 patients who were treated at each of the consortium's participating institutions, making it among the largest cancer genomic datasets available to the scientific community for research. New in this most recent data release is the addition of genomic information from more than 4,000 cfDNA samples. Use and scientific impact continue to increase, with over 20,100+ registered users, 1,700+ total citations, and 20 project publications, reflecting a sustained and growing adoption by the research community.